Budget impact analysis of medicines: updated systematic review and implications.

Ameliorative Impact of Silymarin on the Male Reproductive System: An Updated Systematic Review

Background and objectives: Numerous studies have evaluated the effects of silymarin on sperm quality and its neutralization impact of various toxins on the male reproductive system. However, these studies as a whole have not been summarized and categorized yet. Silymarin is a flavonoid and known as a powerful antioxidant compound in the treatment of many diseases including liver disorders, rhin...

Effectiveness of Fresh Frozen Plasma in Management of Acute Organophosphate Intoxicated Patients: An Updated Systematic Review and Meta-Analysis

The prevalence of attention deficit hyperactivity disorder in Iran: An updated systematic review

Background: Attention deficit hyperactivity disorder (ADHD) is among the most common neurodevelopmental disorders in children and adolescents. There is a controversy over the true prevalence of ADHD in Iran, the knowledge of which is crucial for allocating health care resources and identifying research priorities. This is an updated systematic review of the prevalence of ADHD in Iranian childre...

Acellular pertussis vaccine efficacy: An updated systematic review and meta –analysis

Background: Recent studies indicate an increased incidence of pertussis disease in recent years. The aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the Expanded Program on Immunization) and for high-risk adults in Iran through updating current best available evidence.   Methods: We performed a syste...

Exploring the implications of a fixed budget for new medicines: a study of reimbursement of new medicines in Australia and New Zealand.

OBJECTIVE Spending on medicines under the Pharmaceutical Benefits Scheme (PBS) represents the ninth largest expense to the Federal Government. A recent report by the Commission of Audit to the Federal Government suggested spending on the PBS is unsustainable and a capped budget, similar to New Zealand's PHARMAC model, may be required to contain costs. The objective of the present study was to c...